Synthesis of Two Novel Copper (II) Complexes as Potential Inhibitors of HIV-1 Protease Enzyme: Experimental and Theoretical Investigations

In this study, we report the synthesis of two new copper complexes: [Cu(C$_{11}$H$_{7}$O$_{2}$)(SCN)(C$_{10}$H$_{8}$N$_{2}$)], denoted as (C-1), and [Cu(C$_{11}$H$_{7}$O$_{2}$) (C$_{12}$H$_{8}$N$_{2}$) Cl]·H$_{2}$O, denoted as (C-2). They are based on 2,2′-bipyridine or 1,10-phenanthroline and 2-hydroxy-1-naphtaldehyde ligands. The obtained complexes were characterized by FT-IR, UV-visible spectroscopy, and single-crystal X-ray diffraction analysis. Molecular docking was employed to predict the binding mode involved in the interaction between the two synthetic copper (II) complexes and HIV-1 protease enzyme. The X-ray structural analysis revealed that the crystal structures of both complexes are mainly stabilized by several intra- and intermolecular hydrogen bonds. The fingerprint plots associated with the Hirshfeld surfaces of both complexes clearly show that H···H interactions provide the largest contributions. According to the docking results, the synthesized complexes exhibit promising features which enable them to be bound to the HIV-protease enzyme

Influence de quelques paramètres intrinsèques liés à l’animal sur la fréquence des mammites subcliniques des vaches laitières

The aim of this study is to determine the risk factors for subclinical mastitis, and the effect of the breed, number and stage of lactation of cows on their frequency in dairy cattle farms in the Constantine region. The study involved 20 small and medium herds of dairy cattle from the Constantine region in eastern Algeria. A survey was conducted for the collection of data concerning: the number of cows, the exploited breeds end the type of breeding. The California Mastitis Test (CMT) was carried out for the detection of subclinical mastitis. The results of the survey show that Prim'Holstein is the most exploited breed by dairy farmers. The number of dairy cows exploited ranges from 3 to 80 cows. Animal housing consists of concrete floor in 95% of farms. The results of CMT show that the race most affected by subclinical mastitis is Montbeliarde, thus, the incidence of mastitis is higher in the first and third thirds of lactation, however, the incidence of mastitis has been little modified by the lactation number of the cows. Key words: Dairy cows, Subclinical mstitis, Survey, CMT, ConstantineL’objectif de cette étude consiste à déterminer les facteurs de risque des mammites subcliniques ainsi que l’effet de la race, du numéro et du stade de lactation des vaches sur leur fréquence dans les élevages de bovins laitiers de la région de Constantine. L’étude a concerné 20 petits et moyens troupeaux de bovins laitiers de la région de Constantine à l’Est algérien. Une enquête a été réalisée pour la collecte des données concernant le nombre de vaches, les races exploitées et le type d’élevage. Le California Mastitis Test (CMT) a été réalisé pour la détection des mammites subcliniques. Les résultats de l’enquête montrent que la Prim’Holstein est la race la plus exploitée par les producteurs laitiers. Le nombre de vaches laitières exploitées varie de 3 à 80 vaches. Le logement des animaux est constitué d’un sol bétonné dans 95% des exploitations. Les résultats du CMT montrent que la race la plus affectée par les mammites subcliniques est la Montbéliarde, ainsi, la fréquence des mammites est plus élevée au 1er tiers et au dernier tiers de lactation, cependant, la fréquence des mammites a été peu modifiée par le numéro de lactation des vaches. Mots clés : bovins laitiers, mammites subcliniques, enquête, CMT, Constantin

Innovative technologies for under-resourced language documentation: The BULB Project

International audienceThe project Breaking the Unwritten Language Barrier (BULB), which brings together linguists and computer scientists, aims at supporting linguists in documenting unwritten languages. In order to achieve this we will develop tools tailored to the needs of documentary linguists by building upon technology and expertise from the area of natural language processing, most prominently automatic speech recognition and machine translation. As a development and test bed for this we have chosen three less-resourced African languages from the Bantu family: Basaa, Myene and Embosi. Work within the project is divided into three main steps: 1) Collection of a large corpus of speech (100h per language) at a reasonable cost. After initial recording, the data is re-spoken by a reference speaker to enhance the signal quality and orally translated into French. 2) Automatic transcription of the Bantu languages at phoneme level and the French translation at word level. The recognized Bantu phonemes and French words will then be automatically aligned. 3) Tool development. In close cooperation and discussion with the linguists, the speech and language technologists will design and implement tools that will support the linguists in their work, taking into account the linguists' needs and technology's capabilities. The data collection has begun for the three languages. For this we use standard mobile devices and a dedicated software—LIG-AIKUMA, which proposes a range of different speech collection modes (recording, respeaking, translation and elicitation). LIG-AIKUMA 's improved features include a smart generation and handling of speaker metadata as well as respeaking and parallel audio data mapping

Innovative technologies for under-resourced language documentation: The BULB Project

International audienceThe project Breaking the Unwritten Language Barrier (BULB), which brings together linguists and computer scientists, aims at supporting linguists in documenting unwritten languages. In order to achieve this we will develop tools tailored to the needs of documentary linguists by building upon technology and expertise from the area of natural language processing, most prominently automatic speech recognition and machine translation. As a development and test bed for this we have chosen three less-resourced African languages from the Bantu family: Basaa, Myene and Embosi. Work within the project is divided into three main steps: 1) Collection of a large corpus of speech (100h per language) at a reasonable cost. After initial recording, the data is re-spoken by a reference speaker to enhance the signal quality and orally translated into French. 2) Automatic transcription of the Bantu languages at phoneme level and the French translation at word level. The recognized Bantu phonemes and French words will then be automatically aligned. 3) Tool development. In close cooperation and discussion with the linguists, the speech and language technologists will design and implement tools that will support the linguists in their work, taking into account the linguists' needs and technology's capabilities. The data collection has begun for the three languages. For this we use standard mobile devices and a dedicated software—LIG-AIKUMA, which proposes a range of different speech collection modes (recording, respeaking, translation and elicitation). LIG-AIKUMA 's improved features include a smart generation and handling of speaker metadata as well as respeaking and parallel audio data mapping

Theory and description in African Linguistics: Selected papers from the 47th Annual Conference on African Linguistics

The papers in this volume were presented at the 47th Annual Conference on African Linguistics at UC Berkeley in 2016. The papers offer new descriptions of African languages and propose novel theoretical analyses of them. The contributions span topics in phonetics, phonology, syntax, semantics, and pragmatics and reflect the typological and genetic diversity of languages in Africa. Four papers in the volume examine Areal Features and Linguistic Reconstruction in Africa, and were presented at a special workshop on this topic held alongside the general session of ACAL

Theory and description in African Linguistics: Selected papers from the 47th Annual Conference on African Linguistics

The papers in this volume were presented at the 47th Annual Conference on African Linguistics at UC Berkeley in 2016. The papers offer new descriptions of African languages and propose novel theoretical analyses of them. The contributions span topics in phonetics, phonology, syntax, semantics, and pragmatics and reflect the typological and genetic diversity of languages in Africa. Four papers in the volume examine Areal Features and Linguistic Reconstruction in Africa, and were presented at a special workshop on this topic held alongside the general session of ACAL

Theory and description in African Linguistics: Selected papers from the 47th Annual Conference on African Linguistics

The papers in this volume were presented at the 47th Annual Conference on African Linguistics at UC Berkeley in 2016. The papers offer new descriptions of African languages and propose novel theoretical analyses of them. The contributions span topics in phonetics, phonology, syntax, semantics, and pragmatics and reflect the typological and genetic diversity of languages in Africa. Four papers in the volume examine Areal Features and Linguistic Reconstruction in Africa, and were presented at a special workshop on this topic held alongside the general session of ACAL

Theory and description in African Linguistics: Selected papers from the 47th Annual Conference on African Linguistics

The papers in this volume were presented at the 47th Annual Conference on African Linguistics at UC Berkeley in 2016. The papers offer new descriptions of African languages and propose novel theoretical analyses of them. The contributions span topics in phonetics, phonology, syntax, semantics, and pragmatics and reflect the typological and genetic diversity of languages in Africa. Four papers in the volume examine Areal Features and Linguistic Reconstruction in Africa, and were presented at a special workshop on this topic held alongside the general session of ACAL